Lab TrialsIn rats, binding of GW-501516 to PPARδ recruits the coactivator PGC1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure. Furthermore, in rats treated with GW-501516, increased fatty acid metabolism in skeletal muscle and protection against dietinduced obesity and type II diabetes was observed. In obese rhesus monkeys, GW-501516 increased highdensity lipoprotein (HDL) and lowered verylowdensity lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.
FunctionGW-1516 regulates fat burning through a number of mechanisms. GW-1516 increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing fat loss effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-1516 significantly increases endurance which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-1516 may have a protective effect against obesity.
Uses For GW-1516
- The first and most common use is that of increased endurance. GW-1516 has been banned for professional use due to the advantage it provides to endurance athletes. Those wanting a dramatic increase in endurance levels will find that GW-1516 delivers. It takes effect very quickly and the results can be staggering.
- The second common use for GW-1516 is that of fat loss. Many users turn to GW-1516 as it has shown to melt off fat while still being noncatabolic proving to still hold on to muscle while losing fat.